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Colorectal cancer is a type of cancer that develops in the colon (large intestine) or rectum, which are parts of the digestive system.
It typically starts as a polyp, a small, non-cancerous growth on the inner lining of these organs. If left undetected and untreated, some of these polyps can develop into cancer over time. Colorectal cancer can affect both men and women and is more prevalent in people over the age of 50.
Colorectal cancer is classified into several types based on the specific cells involved and the location within the digestive system.
This is the most common type, making up about 95% of colorectal cancer cases. It originates in the mucus-producing glands in the lining of the colon or rectum.
These are rare and develop in the hormone-producing cells of the intestines. They typically grow slower than other types of colorectal cancer.
These rare tumours develop in the connective tissue cells of the colon or rectum and can be benign or malignant.
Though typically found in the lymph nodes, lymphomas can also develop in the colon or rectum. They start in the lymphatic system, which is part of the body’s immune system.
These rare cancers begin in the blood vessels, muscle layers, or connective tissues of the colon or rectum.
Colorectal cancer may not present noticeable symptoms in its early stages, necessitating regular screening. As the cancer progresses, it can lead to a range of symptoms, including:
Changes in Bowel Habits: As the tumour grows, it may partially block the passage of stool, leading to diarrhoea or constipation.
Rectal Bleeding: As the tumour grows, it may irritate or damage the lining of the colon or rectum, causing bleeding. Depending on where the tumour is located, blood from rectal bleeding can appear bright red or dark in the stool.
Abdominal Discomfort: The tumour may block the bowel, making it difficult for waste to pass. The colon exerts more effort to push stool around the tumour, causing cramps, gas, or a feeling of fullness.
Unexplained Weight Loss: Colorectal cancer can lead to unexplained weight loss as the tumour affects the body’s ability to absorb nutrients. Cancer may also increase the body’s energy expenditure and disrupt normal metabolic processes, contributing to weight loss.
Fatigue: Advanced stages of colorectal cancer can cause chronic fatigue due to the body’s increased effort to fight the disease. Fatigue can also occur if the cancer leads to anaemia.
The exact cause of colorectal cancer is not always known, but several factors can increase the risk of developing it.
The risk of colorectal cancer increases with age, particularly after age 50. This is due to the accumulation of cell divisions and environmental exposures over time that can lead to mutations and cancer development.
Having a close relative with colorectal cancer or polyps before age 60 can increase your risk.
Certain inherited genetic conditions, such as familial adenomatous polyposis (FAP) and Lynch syndrome, significantly increase the risk of colorectal cancer.
Chronic inflammatory conditions of the colon, such as ulcerative colitis or Crohn’s disease, can increase the risk of colorectal cancer. Prolonged inflammation damages the colon lining, increasing cell turnover and the risk of cancer-causing mutations.
People with type 2 diabetes face a higher risk of colorectal cancer, possibly due to shared risk factors such as obesity and insulin resistance, which can elevate insulin levels and promote cancer cell growth.
Diagnosing colorectal cancer typically combines diagnostic procedures and screening tests.
The most thorough method for diagnosing colorectal cancer, where a doctor uses a flexible tube with a camera to inspect the entire colon and rectum. Abnormal areas can be biopsied or polyps removed for examination.
A non-invasive imaging test that uses a CT scanner to create detailed pictures of the colon and rectum. A follow-up colonoscopy is often needed if abnormalities are found.
Tests like the faecal occult blood test and faecal immunochemical test detect hidden blood in the stool, which may indicate cancer. Positive results typically lead to further testing, such as a colonoscopy.
If cancer is suspected during a colonoscopy, a biopsy is taken from the abnormal area to confirm the presence of cancer cells under a microscope.
Surgical treatment aims to remove the cancerous tissue while preserving as much of the healthy colon and rectum as possible.
In early-stage colorectal cancer, the cancerous polyp or a small section of the colon or rectum can be removed during a colonoscopy. This minimally invasive procedure is typically used when the cancer is confined to a small area, has not spread and requires a shorter recovery.
The removal of part or all of the colon containing cancer, with the remaining sections reconnected. A partial or total colectomy may be required when the cancer has spread beyond a small area. This procedure reduces the risk of recurrence by removing the cancerous tissue.
This minimally invasive surgery uses small incisions and a camera to guide the surgeon in removing cancer. It offers a shorter recovery period and less pain compared to traditional open surgery.
Laparoscopic anterior resection, a specific procedure, is used to remove cancer in the rectum and lower colon, preserving healthy tissue and reducing the need for a colostomy while maintaining normal bowel function.
Consult our MOH-accredited specialist for an accurate diagnosis & personalised treatment plan today.
Colorectal cancer prevention involves lifestyle changes, regular screening, and awareness of risk factors. A diet rich in fruits, vegetables, and whole grains, and a reduced consumption of red and processed meats, can lower your risk. Regular physical activity, maintaining a healthy weight, avoiding smoking, and limiting alcohol consumption also contribute to prevention.
Regular screening is recommended, especially for people over 50 and those with a family history of colorectal cancer. Colonoscopies can detect and remove polyps before they become cancerous. Those with a genetic predisposition may require more frequent screenings and preventive measures, including medications or surgery. Following screening guidelines can significantly lower your risk.
Screening frequency depends on your age, family history, and personal risk factors. For most people at average risk, a colonoscopy is recommended every 10 years starting at age 50. However, if you have a family history of colorectal cancer or polyps, screening should begin earlier — typically at age 40, or 10 years before the age at which your relative was diagnosed, whichever comes first. Those with inflammatory bowel disease or known genetic conditions such as Lynch syndrome may require even more frequent monitoring. Dr. Sulaiman will advise on the most appropriate schedule for your individual circumstances.
Yes, colorectal cancer is often curable when detected early. At Stage I, the five-year survival rate exceeds 90%. Even Stage III disease carries a reasonable chance of cure with a combination of surgery and chemotherapy. The likelihood of a successful outcome decreases as the cancer advances, which is why early detection through regular screening is so important. If you have any concerns about your symptoms or risk factors, it is always better to seek assessment sooner rather than later.
Both types arise from the same inner lining of the large bowel, but their location within the body affects how they are managed. Colon cancer is located in the longer upper portion of the large intestine, while rectal cancer occurs in the final 15–20 cm before the anus. Rectal cancers often require a more complex treatment approach, which may include radiotherapy and chemotherapy before or after surgery. The surgical techniques also differ — rectal cancer surgery demands greater precision to preserve the nerves controlling bladder and sexual function, which is an area where robotic-assisted surgery offers a significant advantage.
There are several options available depending on your preference and risk profile:
For most patients, a colonoscopy remains the gold standard as it combines diagnosis and treatment in a single procedure.
There is currently no blood test that can reliably diagnose colorectal cancer on its own. Tumour markers such as CEA (carcinoembryonic antigen) and CA 19-9 can be elevated in colorectal cancer but are not specific enough for screening — they may also be raised in benign conditions such as smoking, infection, or liver disease. These markers are more useful for monitoring treatment response and detecting recurrence after a diagnosis has already been made. A colonoscopy remains the most reliable method for diagnosis.
Robotic-assisted surgery uses the da Vinci Xi surgical system to perform precise, minimally invasive removal of the tumour through small keyhole incisions. Dr. Sulaiman is experienced in robotic colectomy and anterior resection for colorectal cancer. Compared to open surgery, the robotic approach typically offers reduced blood loss, lower risk of complications, a shorter hospital stay, and a faster return to normal activity. For rectal cancer in particular, the enhanced three-dimensional visualisation and precision of robotic instruments makes it easier to work in the narrow confines of the pelvis while protecting the nerves responsible for bladder and sexual function.
Most patients do not require a permanent colostomy. With modern surgical techniques, the majority of colorectal cancers can be treated with bowel-preserving surgery, where the healthy ends of the bowel are reconnected after the tumour is removed. In some cases — particularly for low rectal cancers or emergency situations — a temporary stoma may be needed to allow the bowel to heal, but this is usually reversed in a subsequent procedure. Whether a stoma is required depends on the location and stage of the tumour, as well as your overall health. Dr. Sulaiman will discuss all possibilities with you before any operation.
Yes. First-degree relatives — parents, siblings, and children — of someone diagnosed with colorectal cancer have approximately two to three times the average risk of developing the condition themselves. It is recommended that they begin screening at age 40, or 10 years before the age at which you were diagnosed, whichever is earlier. Informing your family members of your diagnosis gives them the opportunity to take preventive action. Dr. Sulaiman’s team is happy to advise family members on appropriate screening options.
Yes. Colorectal cancer is the most common cancer among men in Singapore and the second most common cancer overall. Singapore also reflects a global trend of rising incidence among younger adults — cases in people under 50 are increasing, which has led to growing calls for earlier screening in those with risk factors. If you are experiencing symptoms such as rectal bleeding, changes in bowel habits, or unexplained weight loss — regardless of your age — it is important to seek a prompt evaluation.
This depends on the stage and characteristics of your cancer. For early-stage disease, surgery alone may be curative. For Stage III cancers — where lymph nodes are involved — adjuvant chemotherapy is usually recommended after surgery to reduce the risk of recurrence. For rectal cancer, neoadjuvant (pre-operative) chemoradiation may be used to shrink the tumour before surgery, improving the chances of complete removal and bowel preservation. Your treatment plan will be developed in a multidisciplinary setting, and Dr. Sulaiman will coordinate your care with oncologists and radiation specialists as needed.
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*Extended Panel
MbChB (Sheffield)
M.Med (Surgery)
FRCSEd (General Surgery)
蘇萊曼·尤索夫博士
Dr. Sulaiman Bin Yusof is a Senior Consultant colorectal and general surgeon with over 15 years of specialist experience. Fellowship-trained at the Peter MacCallum Cancer Centre in Melbourne, he is one of a select group of surgeons in Singapore listed on the da Vinci Xi surgeon locator — reflecting his expertise in robotic-assisted colorectal surgery.
Recipient of the Singapore Health Quality Service Star Award 2023, Dr. Sulaiman is known for clear communication, unhurried consultations, and outcomes-focused care across his five clinic locations in Singapore.
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